Spectrofluorimetric determination of fluoroquinolones in pharmaceutical preparations
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, vol.72, no.1, pp.138-143, 2009 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 72 Issue: 1
- Publication Date: 2009
- Doi Number: 10.1016/j.saa.2008.08.017
- Journal Name: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.138-143
- Istanbul University Affiliated: Yes
Abstract
Simple, rapid and highly sensitive spectrofluorimetric method is presented for the determination of four fluoroquinolone (FQ) drugs. ciprofloxacin, enoxacin, norfloxacin and moxifloxacin in pharmaceutical preparations. Proposed method is based on the derivatization of FQ with 4-chloro-7-nitrobenzofurazan (NBD-Cl) in borate buffer of pH 9.0 to yield a yellow product.