FAPI-Negative FDG-Avid Metastatic Relapse of Breast Cancer on PET/CT.

Civan C., Has Simsek D., Isik E. G., Sanli Y., Kuyumcu S.

Clinical nuclear medicine, vol.48, no.8, 2023 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 48 Issue: 8
  • Publication Date: 2023
  • Doi Number: 10.1097/rlu.0000000000004704
  • Journal Name: Clinical nuclear medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
  • Keywords: 18F-FDG, 68Ga-FAPI, breast cancer, PET/CT
  • Istanbul University Affiliated: Yes

Abstract

A 69-year-old woman with breast cancer underwent 18F-FDG PET/CT because of the increased CA-15-3 level. 18F-FDG PET/CT showed multiple hypermetabolic lymph nodes (LNs) in the neck and mediastinum. The patient was also referred for 68Ga-fibroblast activation protein inhibitor (FAPI) 04 PET/CT for further evaluation. However, 18F-FDG-avid LNs were FAPI-negative on 68Ga-FAPI-04 PET/CT. Supraclavicular LN biopsy confirmed the metastasis of breast cancer. Recent reports have focused on the potential of FAPI PET imaging in breast cancer; however, this case highlights that false-negative 68Ga-FAPI-04-PET/CT findings should also be considered while evaluating metastatic spread.