Predictive Role of Midtreatment Changes in Survivin, GSTP1, and Topoisomerase 2 alpha Expressions for Pathologic Complete Response to Neoadjuvant Chemotherapy in Patients With Locally Advanced Breast Cancer

Eralp, Yesim; Keskin, Serkan; Akisik, Ebru; Akisik, Elif; Igci, Abdullah; Muslumanoglu, Mahmut; Yilmaz, Sabri; Tunaci, Mehtap; Camlica, Hakan; Tuzlali, Sitki; Saip, Pınar; Dalay, Nejat; Ozmen, Vahit; Topuz, Erkan

doi:10.1097/coc.0b013e318243913f

Predictive Role of Midtreatment Changes in Survivin, GSTP1, and Topoisomerase 2 alpha Expressions for Pathologic Complete Response to Neoadjuvant Chemotherapy in Patients With Locally Advanced Breast Cancer

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Eralp Y., Keskin S., Akisik E. E., Akisik E., Igci A., Muslumanoglu M., ...More

AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, vol.36, no.3, pp.215-223, 2013 (SCI-Expanded)

Publication Type: Article / Article
Volume: 36 Issue: 3
Publication Date: 2013
Doi Number: 10.1097/coc.0b013e318243913f
Journal Name: AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.215-223
Keywords: breast cancer, mRNA, response to neoadjuvant chemotherapy, survivin, GSTP1, topoisomerase 2A, GLUTATHIONE-S-TRANSFERASE, SURGICAL ADJUVANT BREAST, ANTHRACYCLINE-BASED CHEMOTHERAPY, PROJECT PROTOCOL B-27, II-ALPHA, PREOPERATIVE CHEMOTHERAPY, ESOPHAGEAL CANCER, SYSTEMIC THERAPY, TAXOL RESISTANCE, DRUG-RESISTANCE
Istanbul University Affiliated: Yes

Abstract

Introduction: The primary aim of this study is to investigate the effect of change in the expression levels of survivin, glutathione-S-transferase P1 (GSTP1), and topoisomerase 2 alpha (TOP2A) on the response to antracyclin-based and taxane-based neoadjuvant chemotherapy.