Efficacy and Safety of Imatinib Treatment in Elderly Patients With Chronic Myeloid Leukemia: Real-Life Data and a Single-Center Experience


EŞKAZAN A. E. , Ozmen D., ÖZTAŞ M., Bektas F., Bayraktar E. A. , Sadri S. , ...More

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, vol.21, no.8, pp.549-557, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 8
  • Publication Date: 2021
  • Doi Number: 10.1016/j.clml.2021.04.005
  • Title of Journal : CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
  • Page Numbers: pp.549-557
  • Keywords: Age, Charlson comorbidity index (CCI), Comorbidity, Chronic myeloid leukemia, Imatinib, CLINICAL CHARACTERISTICS, CML, AGE, COMORBIDITIES, IMPACT

Abstract

We retrospectively compared the efficacy and safety of frontline imatinib between elderly patients (>= 60 years old) and younger patients ( <60 years old) with chronic myeloid leukemia (CML). Response rates were similar in both groups. Event-free survival was comparable, and overall survival-when non-CML-related deaths were censored-was also similar. Age at diagnosis and the Charlson comorbidity index were significantly associated with overall survival. In the era of tyrosine kinase inhibitors, survival of patients with CML is determined more by comorbidities than by the disease itself.