Synthesis, antibacterial and antifungal evaluation of thio- or piperazinyl-substituted 1,4-naphthoquinone derivatives

Ibis C., Ozsoy-Gunes Z., Tuyun A. F., Ayla S. S., Bahar H., STASEVYCH M. V., ...More

Journal of Sulfur Chemistry, vol.37, no.5, pp.477-487, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.1080/17415993.2016.1187734
  • Journal Name: Journal of Sulfur Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.477-487
  • Keywords: Piperazine, thiol, bipiperidine, 1, 4-naphthoquinone, antibacterial, antifungal activity, AGENTS, SAR
  • Istanbul University Affiliated: No

Abstract

A series of S-, S,S-, S,O-, N- and N,S-derivatives from 2,3-dichloro-1,4-naphthoquinone compound 1 were synthesized in different reaction media and evaluated for their antibacterial and antifungal activities. The structures of the novel products were characterized by spectroscopic methods, such as microanalysis, H-1 NMR, C-13 NMR and MS. Among the tested compounds 9, 12 and 18 are the most effective compounds against Candida tenuis as potent antifungal compounds. Compound 9 is also the most effective compound against Staphylococcus aureus as a potent antifungal compound.