Synthesis, antibacterial and antifungal evaluation of thio- or piperazinyl-substituted 1,4-naphthoquinone derivatives

Ibis C., Ozsoy-Gunes Z., Tuyun A. F., Ayla S. S., Bahar H., STASEVYCH M. V., ...Daha Fazla

Journal of Sulfur Chemistry, cilt.37, sa.5, ss.477-487, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 37 Sayı: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1080/17415993.2016.1187734
  • Dergi Adı: Journal of Sulfur Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.477-487
  • Anahtar Kelimeler: Piperazine, thiol, bipiperidine, 1, 4-naphthoquinone, antibacterial, antifungal activity, AGENTS, SAR
  • İstanbul Üniversitesi Adresli: Hayır

Özet

A series of S-, S,S-, S,O-, N- and N,S-derivatives from 2,3-dichloro-1,4-naphthoquinone compound 1 were synthesized in different reaction media and evaluated for their antibacterial and antifungal activities. The structures of the novel products were characterized by spectroscopic methods, such as microanalysis, H-1 NMR, C-13 NMR and MS. Among the tested compounds 9, 12 and 18 are the most effective compounds against Candida tenuis as potent antifungal compounds. Compound 9 is also the most effective compound against Staphylococcus aureus as a potent antifungal compound.