Çocuklarda Yineleyen Tonsillofarenjitte D Vitaminin Rolü

Yıldız İ., Ünüvar E., Zeybek Ü., Toptaş B., Cacına C., Toprak S., ...More

Çocuk Dergisi, vol.12, no.3, pp.132-138, 2012 (Peer-Reviewed Journal)

  • Publication Type: Article / Article
  • Volume: 12 Issue: 3
  • Publication Date: 2012
  • Doi Number: 10.5222/j.child.2012.132
  • Journal Name: Çocuk Dergisi
  • Journal Indexes: TR DİZİN (ULAKBİM)
  • Page Numbers: pp.132-138
  • Istanbul University Affiliated: Yes


Aim: The exact etiology of recurrent tonsillopharyngitis in

children is not clear. Recurrent tonsillitis in children has

multifactorial etiology like most of the diseases in childhood.

In this study, our aim was to determine the potential role of

vitamin D in recurrent tonsillitis by measuring serum 25-OH

vitamin D levels and determining the vitamin D receptor

polymorphism among children with recurrent tonsillitis.

Material and Methods: Eighty-four children with recurrent

tonsillitis and seventy-one healthy children aging between 2

and 10 years were enrolled in this study. Serum 25-OH vitamin D level was measured with ELISA and vitamin D receptor gene polymorphism (Apa 1, Taq 1, Fok 1) was determined by PCR. Serum 25-OH vitamin D level below 50 nmol/L

was accepted as vitamin D deficiency. The vitamin D receptor gene polymorphism in each group was compared.

Results: The mean age was 5.6±2.4 and 6.1±2.7 years in

the study and control groups, respectively. The average

serum 25-OH vitamin D level was 142.7±68.1 nmol/L in the

study group and 192.3±56.1 nmol/L in the control group.

There was a significant difference between the groups

(p<0.01). In the study group, 4.7 % (n=4) of the children

had serum 25 OH vitamin D levels below 50 nmol/L. None

of the children in the control group had serum 25-OH vitamin D level below 50 nmol/L. There was no significant

differences in vitamin D receptor gene polymorphisms between groups.

Conclusion: Serum 25-OH vitamin D levels in recurrent

tonsillitis group were lower than those in the healthy children. But, there was no difference in the incidence of vitamin

D receptor gene polymorphism between the two groups.