Inborn errors of immunity (IEI) are a heterogeneous group of diseases, typically characterized by recurrent ve severe infections, autoimmunity, autoinflammatory, allergic diseases and cancer. Since their immune response to pathogens are impaired, they have high risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which has spread more than 180 countries. It is reported that two groups of people were prone to life-threatening coronavirus disease 2019 (COVID-19): aged (>65 years of age) and people with comorbidities such as hypertension, cardiovascular diseases, chronic lung, renal and liver diseases, diabetes mellitus, obesity, including immunodeficiencies. The aim of this paper is to present information about the new coronavirus, modes of transmission, clinical findings, diagnostic procedures, treatment modalities of COVID-19 to the physicians who is caring patients with primary immunodeficiency. Patients with primary immunodeficiencies, must exclusively rely on hygiene and protective measures to combat SARS-CoV-2, since vaccines or effective antiviral treatments against COVID-19 are still not available.