Carbapenemases from the Laboratory to the Clinic in Gram-Negative Enteric Bacteria

Budak S., AKTAŞ Z., Erdem H.

MEDITERRANEAN JOURNAL OF INFECTION MICROBES AND ANTIMICROBIALS, vol.1, 2012 (ESCI) identifier

  • Publication Type: Article / Review
  • Volume: 1
  • Publication Date: 2012
  • Journal Name: MEDITERRANEAN JOURNAL OF INFECTION MICROBES AND ANTIMICROBIALS
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Keywords: Carbapenem resistance, carbapenemases, enteric bacteria, METALLO-BETA-LACTAMASE, KLEBSIELLA-PNEUMONIAE CARBAPENEMASE, PSEUDOMONAS-AERUGINOSA, HYDROLYZING ENZYME, RESISTANT STRAIN, GENE BLA(IMP-4), KPC, ENTEROBACTERIACEAE, PATHOGENS, SURVEILLANCE
  • Istanbul University Affiliated: Yes

Abstract

In gram-negative bacteria, antimicrobial resistance related to beta-lactamases is a serious problem in the management of healthcare-related infections. Enzymatic resistance due to beta-lactamases is mostly transferred via plasmids, which results in multiple drug resistance and difficulties in the treatment. Carbapenems are the most reliable group of antimicrobials in the treatment of infections caused by these resistant bacteria. In this report, we aimed to reveal the antimicrobial resistance-related carbapenemase-mediated resistance to carbapenems, the clinical significance, and the detectability of the resistance in the laboratory.