Nasal administration of heparin-loaded microspheres based on poly(lactic acid)

Yildiz A., Okyar A., Baktir G., Araman A., Özsoy Y.

Farmaco, cilt.60, ss.919-924, 2005 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.farmac.2005.08.004
  • Dergi Adı: Farmaco
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, International Pharmaceutical Abstracts
  • Sayfa Sayıları: ss.919-924
  • İstanbul Üniversitesi Adresli: Evet

Özet

In this study, heparin-loaded microspheres having smooth surface and small particle size were designed in order to provide the absorption of heparin through nasal mucosa. For this purpose, microspheres at different polymer/drug ratios (1:10, 1:2.5 and 1:1) and at different concentrations of polyvinyl alcohol, emulsifying agent (1.5% and 2.5% w/v) were prepared by solvent evaporation method with poly(lactic acid). The microspheres were for evaluated shape and surface properties, particle size, production yield, encapsulation efficiency and in vitro drug release. Based on the in vitro data, selected microspheres were applied by nasal route to Wistar albino rats. According to in vivo studies, heparin-loaded microspheres may be used by nasal route as an alternative to parenteral route. © 2005 Elsevier SAS. All rights reserved.