Immunomodulating Hydrogels as Stealth Platform for Drug Delivery Applications

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Rezaei Z., Yilmaz-Aykut D., Tourk F. M., Bassous N., Barroso-Zuppa M., Shawl A. I., ...More

PHARMACEUTICS, vol.14, no.10, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 14 Issue: 10
  • Publication Date: 2022
  • Doi Number: 10.3390/pharmaceutics14102244
  • Journal Name: PHARMACEUTICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, EMBASE, Directory of Open Access Journals
  • Keywords: hydrogels, immune modulation, biomaterials, foreign body response, tissue engineering, REGULATORY T-CELLS, IMMUNE MODULATION, BIOMATERIALS, ANTIGEN, CANCER, ACID, IMMUNOTHERAPY, MACROPHAGES, PERFORMANCE, STRATEGIES
  • Open Archive Collection: AVESIS Open Access Collection
  • Istanbul University Affiliated: No

Abstract

Non-targeted persistent immune activation or suppression by different drug delivery platforms can cause adverse and chronic physiological effects including cancer and arthritis. Therefore, non-toxic materials that do not trigger an immunogenic response during delivery are crucial for safe and effective in vivo treatment. Hydrogels are excellent candidates that can be engineered to control immune responses by modulating biomolecule release/adsorption, improving regeneration of lymphoid tissues, and enhancing function during antigen presentation. This review discusses the aspects of hydrogel-based systems used as drug delivery platforms for various diseases. A detailed investigation on different immunomodulation strategies for various delivery options and deliberate upon the outlook of such drug delivery platforms are conducted.