HLA alleles and haplotypes in the Turkish population: relatedness to Kurds, Armenians and other Mediterraneans

Arnaiz-Villena A., Karin M., Bendikuze N., Gomez-Casado E., Moscoso J., Silvera C., ...Daha Fazla

TISSUE ANTIGENS, cilt.57, sa.4, ss.308-317, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 57 Sayı: 4
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1034/j.1399-0039.2001.057004308.x
  • Dergi Adı: TISSUE ANTIGENS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.308-317
  • Anahtar Kelimeler: HLA, Turks, Kurds, Armenians, Jews, Cretans, Iberians, Lebanese, Egyptians, Greeks, Berbers, Algerians, Iranians, PHYLOGENETIC TREES, ASHKENAZI JEWS, SPANIARDS, BASQUES, POLYMORPHISM, FREQUENCIES, MOROCCAN, ALGERIANS, SAMPLE, GENES
  • İstanbul Üniversitesi Adresli: Evet

Özet

Turkish and Kurdish HLA profiles are studied for the first time. The comparative study of their allele frequencies, characteristic haplotypes, genetic distances with other Mediterraneans is complemented by neighbor-joining dendrograms and correspondence analyses. Turks, Kurds, Armenians, Iranians, Jews, Lebanese and other (Eastern and Western) Mediterranean groups seem to share a common ancestry: the older "Mediterranean" substratum. No sign of the postulated Indo-European (Aryan) invasion (1200 B.C.) is detected by our genetic analysis. It is concluded that this invasion, if occurred, had a relatively few invaders in comparison to the already settled populations. i.e. Anatolian Hittite and Hurrian groups (older than 2000 B.C.). These may have given rise to present-day Kurdish, Armenian and Turkish populations.