The Importance of Extranodal Extension Grading in Laryngeal Squamous Cell Carcinoma

Kara H., Aydemir L., Büyük M., Bozbora E., Toraman K., Pamuk S., ...Daha Fazla

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, cilt.173, sa.3, ss.660-670, 2025 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 173 Sayı: 3
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1002/ohn.1297
  • Dergi Adı: OTOLARYNGOLOGY-HEAD AND NECK SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.660-670
  • Anahtar Kelimeler: cancer, extra-nodal extension, larynx, lymph node density
  • İstanbul Üniversitesi Adresli: Evet

Özet

ObjectiveThe primary objective was to investigate the effect of extra-nodal extension (ENE) grading on the survival of pN-positive patients with laryngeal squamous cell carcinoma (LSCC).Study DesignA retrospective cohort study.SettingA tertiary referral center.MethodsThe patients with LSCC were retrospectively reviewed. The histopathological slides of patients were re-examined, and ENE was graded. Survival analyses were performed.ResultsSeventy-six patients were enrolled in this study. The average age of patients was 61.29 years. 3-year overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) rates were 69.7%, 73.7%, and 73.7%, respectively. ENE grading had no statistically significant impact on survival rates.ConclusionWhile the presence of ENE in more than 4 lymph nodes, lymph node density (LND) greater than 0.2, poor histologic differentiation, and not receiving chemotherapy were identified as independent poor prognosticators in LSCC, the study did not show any effect of ENE grading on survival rates.