Akademik Veri Yönetim Sistemi
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS, cilt.74, sa.1, ss.35-43, 2001 (SCI-Expanded)
Objective: To evaluate the efficacy of Neo-Penotran((R)) pessaries (metronidazole 500 mg + miconazole nitrate 100 mg) in candidal, bacterial and trichomonal vaginitis and in mixed vaginal infections. Method. Ninety-seven patients with clinical diagnosis of vaginitis entered this open, non-comparative study. Each patient inserted one pessary twice daily for 7 days. Gynecological and microbiological assessments were carried out before, and 8-10/21-23 days after the start of treatment. Results: Vaginitis symptoms were resolved in 91% of the 74 patients evaluated, and improved in a further 7%. Microbiological cure rates were 97.3% for trichomonal, 86.6% for bacterial and 81% for candidal vaginitis. Recurrence rates were 2.7, 3.8 and 16.1%, respectively. Overall microbiological cure rate for mixed infections was 86%, with 93% for trichomonal + bacterial, and 73% for bacterial + candidal vaginitis. In two out of three cases with trichomonal + bacterial + candidal infection, the microorganisms were eradicated completely. Conclusion: Neo-Penotran((R)) provides immediate and effective treatment for vaginitis, irrespective of single or multiple infection, even when the diagnosis may be uncertain. (C) 2001 International Federation of Gynecology and Obstetrics. All rights reserved.