Akademik Veri Yönetim Sistemi
OPTICS AND SPECTROSCOPY, cilt.110, sa.4, ss.508-512, 2011 (SCI-Expanded)
Simple, rapid and highly sensitive spectrofluorimetric methods were developed for the determination of venlafaxine in pure and pharmaceutical preparations. The proposed methods were based on the reaction of venlafaxine as n-electron donor with pi-acceptors namely, p-bromanil and p-chloranil. The method for the determination of venlafaxine over a concentration range of 5-100 and 5-150 ng/mL, for p-bromanil and p-chloranil methods, respectively. The intra- and inter-day precisions were satisfactory, the relative standard deviations did not exceed 1.69%. The proposed method was successfully applied to the determination of venlafaxine in its pharmaceutical preparations with good accuracy; the mean recovery percentages were 99.80%. The results were compared favorably with those of the reference method.