Beyond the heart - Exploring the therapeutic potential of PDE3 inhibitors
Journal of Research in Pharmacy, cilt.27, sa.6, ss.2218-2241, 2023 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 27 Sayı: 6
- Basım Tarihi: 2023
- Doi Numarası: 10.29228/jrp.512
- Dergi Adı: Journal of Research in Pharmacy
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.2218-2241
- Anahtar Kelimeler: anti-inflammatory disease, anticancer, COVID-19, drug repositioning, PDE3 inhibitors, phosphodiesterase, respiratory disease
- İstanbul Üniversitesi Adresli: Hayır
Özet
Phosphodiesterases (PDEs) consist of an enzyme family of eleven groups responsible for the hydrolytic breakdown of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). cAMP and cGMP are important secondary messengers that regulate physiological functions. The widespread expression of PDE3 in tissues and organs makes it an attractive therapeutic target. For decades, PDE3 inhibitors have been acknowledged as significant pharmaceutical agents in the treatment of cardiovascular disorders due to their inotropic and vasodilatory actions. Emerging data, however, suggests that the potential therapeutic application of PDE3 inhibitors has gone beyond their traditional cardiovascular applications. This comprehensive review aims to explore the non-cardiovascular developments related to PDE3 inhibitors, exploring their mechanism of action, and clinical trials.