The effects of chronic alpha-tocopherol administration on lipid peroxidation in an experimental model of acute spinal cord injury.

Bozbuga M., Izgi N., Canbolat A.

Neurosurgical review, vol.21, no.1, pp.36-42, 1998 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 1
  • Publication Date: 1998
  • Doi Number: 10.1007/bf01111483
  • Journal Name: Neurosurgical review
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.36-42
  • Istanbul University Affiliated: Yes


Most of the numerous experimental studies to research pathophysiological changes following acute spinal cord injury suggest a two-step mechanism of damage to the spinal cord in which the primary (direct) or mechanical injury caused by the trauma initiates secondary (indirect) or progressive autodestructive injury of the cord. During recent years, free oxygen radical generation and lipid peroxidation have been considered to be responsible for secondary autodestructive injury.