The effects of chronic alpha-tocopherol administration on lipid peroxidation in an experimental model of acute spinal cord injury.

Bozbuga M., Izgi N. , Canbolat A.

Neurosurgical review, vol.21, no.1, pp.36-42, 1998 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 1
  • Publication Date: 1998
  • Doi Number: 10.1007/bf01111483
  • Title of Journal : Neurosurgical review
  • Page Numbers: pp.36-42


Most of the numerous experimental studies to research pathophysiological changes following acute spinal cord injury suggest a two-step mechanism of damage to the spinal cord in which the primary (direct) or mechanical injury caused by the trauma initiates secondary (indirect) or progressive autodestructive injury of the cord. During recent years, free oxygen radical generation and lipid peroxidation have been considered to be responsible for secondary autodestructive injury.