The effects of chronic alpha-tocopherol administration on lipid peroxidation in an experimental model of acute spinal cord injury

Bozbuga M., Izgi N., Canbolat A.

NEUROSURGICAL REVIEW, cilt.21, ss.36-42, 1998 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 21 Konu: 1
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1007/bf01111483
  • Sayfa Sayıları: ss.36-42


Most of the numerous experimental studies to research pathophysiological changes following acute spinal cord injury suggest a two-step mechanism of damage to the spinal cord in which the primary (direct) or mechanical injury caused by the trauma initiates secondary (indirect) or progressive autodestructive injury of the cord. During recent years, free oxygen radical generation and lipid peroxidation have been considered to be responsible for secondary autodestructive injury.