Akademik Veri Yönetim Sistemi
Diğer, ss.1-16, 2024
The emergence of Human papillomavirus (HPV) among the human population in different regions of the world has heightened the interest for new treatment methods. Molecular docking is a reliable and predictive method for screening of new potential antiviral molecules against pathogens. The retrieved 42 high-quality whole-genome sequences of HPV were analysed in view of a stable region existence in the genome. The protein encoded by this stable region was targeted for protein-ligand interaction. Consequently, a target constant region which is responsible for encoding the crystal structure of HPV E7 CR3 domain with various regulatory functions for the virus, was detected. A ligand “Pheophorbide a (C35H36N4O5)” interacts with this protein, which could be used against HPV. As known, Pheophorbide a has also been commercially used for cancer treatments. The predictive results need confirmation with further clinical and in vitro studies. The findings will provide new insights into HPV-human cell interactions, induced immunity, and new methods for HPV treatment.