Ethylene Glycol Induced Hyperoxaluria Increases Plasma and Renal Tissue Asymmetrical Dimethylarginine in Rats: A New Pathogenetic Link in Hyperoxaluria Induced Disorders

Aydin, Hasan; Yencilek, Faruk; Mutlu, Nilguen; Comunoglu, Nil; Koyuncu, Hasbey; Sarica, Kemal

doi:10.1016/j.juro.2009.09.076

Ethylene Glycol Induced Hyperoxaluria Increases Plasma and Renal Tissue Asymmetrical Dimethylarginine in Rats: A New Pathogenetic Link in Hyperoxaluria Induced Disorders

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Aydin H., Yencilek F., Mutlu N., Comunoglu N., Koyuncu H. H., Sarica K.

JOURNAL OF UROLOGY, vol.183, no.2, pp.759-764, 2010 (SCI-Expanded)

Publication Type: Article / Article
Volume: 183 Issue: 2
Publication Date: 2010
Doi Number: 10.1016/j.juro.2009.09.076
Journal Name: JOURNAL OF UROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.759-764
Istanbul University Affiliated: Yes

Abstract

Purpose: The pathogenesis of kidney stones remains elusive. There is some evidence that hyperoxaluria may effect vascular endothelium and many studies link renal stones to atherosclerosis. Also, renal vascular endothelial cells regulate proximal tubular epithelial cell function. We determined the effect of hyperoxaluria on plasma and tissue levels of asymmetrical dimethylarginine. The secondary aim was to determine the effect of verapamil on asymmetrical dimethylarginine.