Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon, cilt.30, sa.10, ss.473-479, 2002 (Scopus)
In that clinical study we aimed to investigate the effects of preoperative and early postoperative started standart and immunonutrient products on nutritional and immune parameters, and clinical outcome of the patients who underwent malign abdominal tumor operation. Sixty patients, ASA II, were randomly divided into 2 groups in our study. Group I patients received isocaloric, isonitrogenic standart oral nutrition, whereas Group II patients received enteral immunonutrition with arginin, RNA nucleotide and omega-3 and omega-6 fatty acids. Studies of immune function and evaluation of nutritional parameters were made for all patients on preoperative 5 and 1, on postoperative day 1 and 5. For nutritional evaluation albumin, prealbumin, retinol binding protein (RBP) and transferrin levels were determined. For immunologic evaluation IL-2Rα, IL-6 levels, and IgG, IgM, CRP, total lymphocytes, T-lymphocytes, B-lymphocytes were determined. In both groups nutritional parameters were significantly decreased on postoperative day 1 (p<0.05). Prealbumin and RBP levels increased in Group II on postoperative day 5 (p<0.05). IL-6 and CRP measurements increased significantly in both groups (p<0.05), but that increment was lower Group in Group II. IL-2Rα levels increased on postoperative day 1 and 5 in Group II. The duration of intensive care stay, hospital stay and antibiotic therapy, and postoperative infection rate were significantly higher in Group I (p<0.05). It was concluded that early immunonutrition in major operations caused; decrease in severity of acute inflamatory reaction (p<0.05), augmentation in cellular immun support, decrease in intensive care stay and hospitalization period (p<0.05).