The Improving Effects of Simvastatin on Erythrocyte Membrane Proteins in Endotoxemic Rats

Creative Commons License

Yorulmaz H., Ateş G., Özkök E., Albeniz I., Tamer A. Ş.

Journal of Pharmacology & Clinical Toxicology, cilt.8, sa.2, ss.1-3, 2020 (Hakemli Dergi)

Özet

The recent studies in patients with inflammation reported that simvastatin inhibited the vascular hyporeactivity and reduced the risk of the sepsis. The

membrane proteins spectrin, ankyrin, actin, band-3, protein 4.1, and glycophorin have important roles in maintaining the structural and functional of the red

blood cells (RBC). In the present study, we aimed to investigate the effects of simvastatin on the membrane proteins of rats treated with lipopolysaccharide

(LPS). Rats were divided into four groups as the control, Endotoxemic (20 mg/kg, i.p. LPS), Simvastatin (20 mg/kg, p.o.), and Simvastatin+Endotoxemic group.

Erythrocyte membrane proteins were detected using the SDS-PAGE. In the endotoxemic group, while the levels of proteins band-3, Protein 4.1, ankyrin were to

decreased, spectrins, Actin, Glycophorins were extremely lower compared to other groups. In addition, simvastatin administration in endotoxemic animals was

found to improve the distrupted membrane proteins which may suggest a compensatory defense mechanism supporting the RBC function.