Y-90 Microsphere Radioembolization Dosimetry Y-90 Mikroküre Radyoembolizasyon Dozimetri Kılavuzu
Nuclear Medicine Seminars, cilt.11, sa.1, ss.39-47, 2025 (Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 11 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.4274/nts.galenos.2025.03521
- Dergi Adı: Nuclear Medicine Seminars
- Derginin Tarandığı İndeksler: Scopus, Academic Search Premier
- Sayfa Sayıları: ss.39-47
- Anahtar Kelimeler: Y-90 dosimetry, Y-90 microsphere dosimetry, Y-90 radioembolization treatment dosimetry
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- İstanbul Üniversitesi Adresli: Evet
Özet
The need for dosimetric calculations has arisen to enhance the therapeutic efficacy of Yttrium-90 (Y-90) microsphere therapy, determine tumor absorbed dose threshold values, and accurately identify lung tolerance dose thresholds and liver toxicity thresholds. In microsphere therapies, there are three different dosimetry approaches: standard dosimetry, multicompartment dosimetry, and voxel-based dosimetry. Dosimetric procedures are generally performed using Technetium-99m macroaggregated albumin. However, dosimetry based on scintigraphic images obtained from positron emission tomography/computed tomography (CT) or single photon emission computerized tomography/CT after Y-90 administration is also feasible.