IL-10 and TNF-alpha Gene Polymorphisms in Patients with Celiac Disease


Kekik Ç., OĞUZ F., Karahan G. E., Seyhun Y., Aslan E., Bayramicli O. U., ...Daha Fazla

TURKISH JOURNAL OF IMMUNOLOGY, cilt.16, sa.1, ss.11-16, 2011 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 1
  • Basım Tarihi: 2011
  • Dergi Adı: TURKISH JOURNAL OF IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.11-16
  • İstanbul Üniversitesi Adresli: Evet

Özet

Celiac disease (CD) is an autoimmune disorder characterized by intolerance to ingested gluten. HLA-DQ genes are strongly associated with susceptibility to CD. Non-HLA genes are effective in CD pathogenesis as well as HLA genes. TNF-alpha has a single nucleotidepolymorphism (SNP) at position -308 in promoter region, which has been shown to have association with CD in previous studies. The aim of this study is to investigate the association of TNF-alpha and IL-10 cytokine gene polymorphisms with CD and with DQB1*02 status in patients with celiac disease. Thirty three patients and 93 healthy individuals were included in the present study. GG and AA genotypes in position -308 of TNF-alpha gene had a significantly increased frequency in the patient group and in patients with DQB1*02 when compared to the controls. No significant differences could be established for IL-10 gene polymorphisms within the patients and controls. As a result of all these findings, it might be suggested that there is no significant association of IL-10 gene polymorphism with CD and data on TNF-alpha gene polymorphisms are not sufficient enough to clarify the disease pathogenesis thus indicating roles for other genes within or out of MHC gene region.