A comparative QCM-D study for various drug sorption behaviors and chemical degradation of chitosan/PAA LbL multilayered films

Yilmaz-Aykut D., Yolacan O., DELİGÖZ H.

Journal of Polymer Research, vol.30, no.8, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 8
  • Publication Date: 2023
  • Doi Number: 10.1007/s10965-023-03691-w
  • Journal Name: Journal of Polymer Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Chemical Abstracts Core, Communication Abstracts, Compendex, INSPEC, Metadex, Civil Engineering Abstracts
  • Keywords: Blend films, Chitosan, Drug loading/release behavior, Layer-by-layer, Multilayer degradation, QCM-D
  • Istanbul University Affiliated: Yes

Abstract

In the study, the loading and desorption properties of four different drug models, namely ibuprofen sodium (IBFNa), diclofenac sodium (DCFNa), gentamicin sulfate (GS), and propranolol hydrochloride (P-HCl), through chitosan (CHI)/poly(acrylic acid) (PAA) and poly(styrene sulfonate) (PSS) based multilayers are monitored using quartz crystal microbalance-dissipation (QCM-D) and UV–vis spectrophotometry. Also, the layer growth of single/blend layer-by-layer (LbL) films is studied as a function of the blend composition. 72.5% DCFNa, 37.5% IBFNa, 34.7% GS, and 23.3% P-HCl (w/w) loadings are achieved for the LbL multilayers. Drug-loaded LbL films start to lose their layer integrity under an acidic medium regardless of the drug type while they show large swelling at pH 11. ΔD values significantly increase with IBF-Na and DCF-Na loading whereas this effect is minimal for GS and P-HCl insertion. In vitro analyses reveal that most of the loaded drug is released within five minutes and the desorption percentages are found to be 20.7% and 20.6% at pH 6.8 and 11 at the end of 120 h, respectively. SEM results show that the LbL films partially shrink and become more rugged during IBF uptake and release. The main findings of this study can provide a basis for controlling the loading and release of the desired drug molecule depending on the multilayer composition and stability as a function of the swelling properties and polyelectrolyte-drugs interactions.