Aim: The aim of this study was to assess lipoprotein profile in Qatari patients with type 2 diabetes mellitus (T2DM) and to assess its relationship to coronary artery disease ( CAD). Subjects and methods: This is a prospective study conducted during a period May to October 2004 at the Hamad General Hospital, Doha, State of Qatar. Sample included Qatari nationals ( 180 with diabetes and 180 without) aged 25 to 65 years. Results: The present study revealed that consanguinity, obesity, total cholesterol, reduced HDL-cholesterol and triglyceride were more prevalent in diabetic patients. Also, there was statistically significant difference in biochemistry levels between diabetic patients with CAD and without CAD for age, gender, serum creatinine, triglycerides and BMI. The patients' LDL correlated significantly with total Cholesterol and Lp B. Total cholesterol correlated significantly with triglycerides, Lp B and Lp ( A). Conclusion: The present study showed that Lp( a) may not be an independent risk factor for CAD in patients with DM. (c) 2006 Elsevier Ireland Ltd. All rights reserved.