Hypoxia-inducible factor-1 alpha, hepcidin and interleukin-6 levels in pregnancies with preterm labour


Firat A. A. , Davutoglu E. A. , Ozel A., Gungor Z. B. , Madazli R. , Zengin E. U.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

The aim of the study was to investigate whether serum hypoxia-inducible factor-1alpha (HIF-1 alpha), hepcidin and interleukin-6 (IL-6) concentrations differed between threatened preterm labour (TPL) and uncomplicated pregnancies. This study was conducted on 54 women with TDL pregnancies and 26 healthy pregnant women. The TPL group was further divided into two subgroups according to the gestational age at delivery. Patients who gave birth within 48-72 h after the hospitalisation were referred to as preterm delivery (PD) and who gave birth at >= 37 weeks were referred to as term delivery (TD). Maternal levels of serum HIF-1 alpha, hepcidin and IL-6 were measured with the use of enzyme-linked immunosorbent assay kits. The mean maternal serum HIF-1 alpha, hepcidin and IL-6 levels of PD were significantly higher than TD (p < .001*) and control group (p < .001*). The mean maternal serum HIF-1 alpha and hepcidin levels of TD were no significantly higher than the control group (p=.058, p = .064). The mean maternal serum IL-6 level of TD was significantly higher than the control group (p < .001*). A negative correlation was found between serum concentration of HIF1 alpha, hepcidin, IL-6 with the gestational week of delivery (r = -0.421, p < .01* for HIF-1 alpha; r = -0.578, p < .01* for hepcidin and r = -0.435, p < .01* for IL-6). High levels of HIF-1 alpha, hepcidin and IL-6 may have potential to be used as biomarkers for the differentiation of PD and TD.Impact statement What is already known on this subject? It is known that hypoxia-inducible factor-1alpha (HIF-1 alpha) is a hypoxia marker and hepcidin and interleukin-6 (IL-6) increase in inflammation. Our study is the comparison of maternal serum HIF-1 alpha, hepcidin and IL-6 levels between the TPL group (TD and PD) and healthy control group. What the results of this study add? The present study demonstrates that serum HIF-1 alpha, hepcidin and IL-6 levels were significantly higher in TPD group than uncomplicated group. The mean maternal serum HIF-1 alpha and hepcidin levels of TD were no significantly higher than the control group. What are of these findings for clinical practice and/or further research? High levels of HIF-1 alpha, hepcidin and IL-6 may be biomarkers in the determination of true preterm labour within the TPL group.