LC assay of eletriptan in tablets and in vitro dissolution studies

Sagirli O. , Onal A., Sensoy D.

CHROMATOGRAPHIA, cilt.68, ss.269-273, 2008 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1365/s10337-008-0673-8
  • Sayfa Sayıları: ss.269-273


Eletriptan (ELT) is a new selective serotonin agonist approved for the treatment of acute migraine headaches. A simple and rapid liquid chromatographic method was developed and validated for the assay of ELT in tablets. Chromatography was carried out on a 250 mm x 4.6 mm C(18) column at 30 C. Acetonitrile-15 mM triethylamine solution (adjusted to pH 7.0 using concentrated o-phosphoric acid) (60:40, v/v) mixture was used as mobile phase at 1.0 mL min(-1) flow rate and UV detector was set at 225 nm. A linear response (r(2) = 0.9999) was observed in the range of 0.1-1.6 mu g mL(-1). The method showed good recoveries (100.08 %) and the RSD values for intra- and inter-day precision were 0.78-1.93 and 1.10-2.15%, respectively. The method can be used for quality control assays and in vitro dissolution studies of ELT in tablets.