Arg25Pro (c.915G > C) polymorphism of transforming growth factor beta 1 gene suggests an association with increased risk for Hashimoto's thyroiditis


Vural P., Degirmencioglu S., Dogru-Abbasoglu S., Baki M., OZDERYA A., KARADAG B., ...More

INTERNATIONAL IMMUNOPHARMACOLOGY, vol.28, no.1, pp.521-524, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 1
  • Publication Date: 2015
  • Doi Number: 10.1016/j.intimp.2015.07.019
  • Journal Name: INTERNATIONAL IMMUNOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.521-524
  • Keywords: Hashimoto's thyroiditis, Transforming growth factor beta 1, Polymorphism, Autoimmune, Leu10 Pro, Arg 25 Pro, REGULATORY T-CELLS, TRANSFORMING-GROWTH-FACTOR-BETA-1 GENE, AUTOIMMUNE-THYROIDITIS, RHEUMATOID-ARTHRITIS, CYTOKINE GENOTYPES, TGF-BETA, TGF-BETA-1, DISEASE, GROWTH-FACTOR-BETA-1, SEQUENCE
  • Istanbul University Affiliated: Yes

Abstract

Background: The etiopathogenesis of Hashimoto's thyroiditis (HT) - has not been clearly elucidated although the role of chronic inflammation, endothelial dysfunction, and imbalance between pro- and anti-inflammatory cytokines has been established. Transforming growth factor beta 1 (TGF beta 1) is required to maintain immune homeostasis, and is implicated in lymphocyte infiltration, production of autoantibodies and thyrocyte destruction seen in patients with HT.