Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines.

Gulec C., Coban N., Ozsait-Selcuk B. Ş., Sirma-Ekmekci S., Yildirim O., Erginel-Unaltuna N.

Experimental cell research, cilt.353, ss.6-15, 2017 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 353
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.yexcr.2017.02.028
  • Dergi Adı: Experimental cell research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.6-15
  • Anahtar Kelimeler: Nuclear receptors, Target genes, ChIP-on-chip, Atherosclerosis, ORPHAN RECEPTOR-ALPHA, GLAND HORMONE MELATONIN, LIGAND-BINDING DOMAIN, NUCLEAR RECEPTOR, HEME OXYGENASE-1, TRANSCRIPTIONAL ACTIVATION, ENDOTHELIAL-CELLS, CANCER-CELLS, REV-ERB, IL-6 PRODUCTION
  • İstanbul Üniversitesi Adresli: Evet

Özet

ROR-alpha is a nuclear receptor, activity of which can be modulated by natural or synthetic ligands. Due to its possible involvement in, and potential therapeutic target for atherosclerosis, we aimed to identify ROR-alpha target genes in monocytic and endothelial cell lines.