Identification of potential target genes of ROR-alpha in THP1 and HUVEC cell lines.

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Gulec C., Coban N., Ozsait-Selcuk B. Ş., Sirma-Ekmekci S., Yildirim O., Erginel-Unaltuna N.

Experimental cell research, vol.353, pp.6-15, 2017 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 353
• Publication Date: 2017
• Doi Number: 10.1016/j.yexcr.2017.02.028
• Journal Name: Experimental cell research
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.6-15
• Keywords: Nuclear receptors, Target genes, ChIP-on-chip, Atherosclerosis, ORPHAN RECEPTOR-ALPHA, GLAND HORMONE MELATONIN, LIGAND-BINDING DOMAIN, NUCLEAR RECEPTOR, HEME OXYGENASE-1, TRANSCRIPTIONAL ACTIVATION, ENDOTHELIAL-CELLS, CANCER-CELLS, REV-ERB, IL-6 PRODUCTION
• Istanbul University Affiliated: Yes

Abstract

ROR-alpha is a nuclear receptor, activity of which can be modulated by natural or synthetic ligands. Due to its possible involvement in, and potential therapeutic target for atherosclerosis, we aimed to identify ROR-alpha target genes in monocytic and endothelial cell lines.