Regulatory B cells in myasthenia gravis are differentially affected by therapies
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, vol.5, no.11, pp.1408-1414, 2018 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 5 Issue: 11
- Publication Date: 2018
- Doi Number: 10.1002/acn3.645
- Journal Name: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.1408-1414
- Istanbul University Affiliated: Yes
Abstract
We analyzed the number and functionality of regulatory B (Breg) cells in well-defined myasthenia gravis patients. We first showed a decreased number of circulating CD19(+)CD24(++)CD38(++) Breg cells and an altered functionality of Breg cells in untreated myasthenia gravis patients. Next, we demonstrated that the proportion of circulating Breg cells was restored in myasthenia gravis patients after thymectomy, probably as Breg cells could be sequestered in the myasthenia gravis thymus. In contrast, corticosteroid treatments did not restore and decreased even more the proportion of Breg cells in myasthenia gravis patients. These results clearly demonstrated that two distinct immunomodulatory therapies affect differentially Breg cells.