Multicentre International Study for the Prevention with iAluRil of Radio-induced Cystitis (MISTIC): A Randomised Controlled Study

Palou Redorta, Juan; Sanguedolce, Francesco; Sancho Pardo, Gemma; Romancik, Martin; Vittori, Gianni; Minervini, Andrea; Di Maida, Fabrizio; Lunik, Richard; Colombo, Renzo; Serretta, Vincenzo; Cetinel, Bulent; Bini, Vittorio; Corradengo, Davide; Lazzeri, Massimo

doi:10.1016/j.euros.2021.01.016

Multicentre International Study for the Prevention with iAluRil of Radio-induced Cystitis (MISTIC): A Randomised Controlled Study

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Palou Redorta J., Sanguedolce F., Sancho Pardo G., Romancik M., Vittori G., Minervini A., ...More

EUROPEAN UROLOGY OPEN SCIENCE, vol.26, pp.45-54, 2021 (SCI-Expanded)

Publication Type: Article / Article
Volume: 26
Publication Date: 2021
Doi Number: 10.1016/j.euros.2021.01.016
Journal Name: EUROPEAN UROLOGY OPEN SCIENCE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Directory of Open Access Journals
Page Numbers: pp.45-54
Istanbul University Affiliated: No

Abstract

Background: Radiation-induced cystitis is a common side effect of radiotherapy (RT) to the pelvic area. Hyaluronic acid (HA) and chondroitin sulfate (CS) are components of the urothelial mucosa and positive results have been obtained for intravesical HA/CS instillations for the treatment of urinary tract infections and bladder pain syndrome. HA/CS may also have a protective effect against RT bladder toxicity.