Multicentre International Study for the Prevention with iAluRil of Radio-induced Cystitis (MISTIC): A Randomised Controlled Study


Palou Redorta J., Sanguedolce F., Sancho Pardo G., Romancik M., Vittori G., Minervini A., ...More

EUROPEAN UROLOGY OPEN SCIENCE, vol.26, pp.45-54, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26
  • Publication Date: 2021
  • Doi Number: 10.1016/j.euros.2021.01.016
  • Journal Name: EUROPEAN UROLOGY OPEN SCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Directory of Open Access Journals
  • Page Numbers: pp.45-54
  • Istanbul University Affiliated: No

Abstract

Background: Radiation-induced cystitis is a common side effect of radiotherapy (RT) to the pelvic area. Hyaluronic acid (HA) and chondroitin sulfate (CS) are components of the urothelial mucosa and positive results have been obtained for intravesical HA/CS instillations for the treatment of urinary tract infections and bladder pain syndrome. HA/CS may also have a protective effect against RT bladder toxicity.