Protective effects of vitamin E and selenium on the renal morphology in rats fed high-cholesterol diets

GONCA S., CEYLAN S., YARDIMOĞLU M., DALÇIK H., YUMBUL Z., Kokturk S., ...Daha Fazla

PATHOBIOLOGY, cilt.68, sa.6, ss.258-263, 2000 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 6
  • Basım Tarihi: 2000
  • Doi Numarası: 10.1159/000055935
  • Dergi Adı: PATHOBIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.258-263
  • Anahtar Kelimeler: cholesterol, kidney, vitamin E, selenium, rat, LOW-DENSITY LIPOPROTEIN, FOCAL GLOMERULOSCLEROSIS, GLOMERULAR INJURY, INDUCED HYPERCHOLESTEROLEMIA, MESANGIAL CELLS, LIPIDS, MACROPHAGES, MONOCYTES, LDL
  • İstanbul Üniversitesi Adresli: Hayır

Özet

The histopathological effects of cholesterol and the protective effects of vitamin E and selenium (Se) on renal histology were examined in Sprague-Dawley rats. Light-microscopic evaluation of the renal cortex revealed: glomerular fibrosis, cellular and mesangial proliferation, capillary obliteration and cholesterol crystals in the tubular lumina of the cholesterol-fed group. These results suggest that oxidated LDL (O-LDL) is a cytotoxic factor which stimulates mesangial cell and matrix proliferation. Ultrastructurally, small and large lipid vacuolization in intracapillary lumina, adhesion of epithelial foot processes, mesangial foam cells and polymorphonuclear leukocytes were seen in the cholesterol-fed group. In the groups fed cholesterol + vitamin E, cholesterol + Se and cholesterol + vitamin E + Se, morphological improvements were observed. It appeared that an excess in O-LDL, reactive oxygen species and growth factors might play an important role in the pathogenesis of glomerulosclerosis. In addition, it was concluded that antioxidant therapy may prevent LDL oxidation and generation of free radicals. Copyright (C) 2001 S. KargerAG, Basel.