Akademik Veri Yönetim Sistemi
Biointerface Research in Applied Chemistry, cilt.13, sa.6, 2023 (Scopus)
This study aimed to assess whether peri-implant bone defects with zirconia (ZrO2) and titanium (Ti) implants differ regarding osseointegration and bone regeneration following the application of concentrated growth factor (CGF). A total of three standardized box-shaped defects were created bilaterally in the iliac bones of six male sheep. Dental implants were placed in the center of each defect, and a control implant was placed in intact bone (Control group). After implant placement, three treatment modalities were randomly applied: i) CGF, ii) autogenous bone, and iii) no augmentation (Empty control group). ZrO2 implants were placed on the right ilium and Ti implants on the left ilium of each animal. After an eight-week healing period, one central histological section from each site was prepared. Histomorphometric assessments were performed to evaluate new bone formation (NBF) percentages in the defect area and bone-implant contact (BIC) values. No statistically significant differences existed between BIC values for Ti and ZrO2 implants in CGF, autogenous, and control groups. But in the empty control group, Ti implants had statistically higher BIC values than ZrO2 (p = 0.025, p < 0.05). There were no statistically significant differences between NBF values for Ti and ZrO2 implants in the CGF and autogenous groups. The empty control group’s NBF values for both implant materials were significantly lower than other treatment modalities (p = 0.002, p = 0.007, p < 0.005). ZrO2 and Ti implants have similar osseointegration capacity in grafted or intact bone areas, and the application of CGF to peri-implant bone defects positively affects bone regeneration.