Antioxidant activity of CAPE (caffeic acid phenethyl ester) in vitro can protect human sperm deoxyribonucleic acid from oxidative damage

AYLA, ŞULE; Tunali, Gülden; Bilgic, Bulent; Sofuoglu, Kenan; Ozdemir, A.; Tanriverdi, Gamze; Ozdemir, Semra; SONER, BURAK; Ozturk, Bahar; Karahuseyinoglu, Sercin; Aslan, Esra; Seckin, İsmail

doi:10.1016/j.acthis.2018.01.001

Antioxidant activity of CAPE (caffeic acid phenethyl ester) in vitro can protect human sperm deoxyribonucleic acid from oxidative damage

Atıf İçin Kopyala

AYLA Ş., Tunali G., Bilgic B. E., Sofuoglu K., Ozdemir A. A., Tanriverdi G., ...Daha Fazla

ACTA HISTOCHEMICA, cilt.120, sa.2, ss.117-121, 2018 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 120 Sayı: 2
Basım Tarihi: 2018
Doi Numarası: 10.1016/j.acthis.2018.01.001
Dergi Adı: ACTA HISTOCHEMICA
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.117-121
İstanbul Üniversitesi Adresli: Evet

Özet

Purpose: Sperm processing (e.g., centrifugation) used in preparation for assisted reproduction can result in excessive generation of reactive oxygen species (ROS) and potential sperm damage. The use of antioxidants during sperm processing has been shown to prevent iatrogenic sperm damage, including DNA damage. In this study, we evaluated the effect of caffeic acid phenethyl ester (CAPE) on oxidative stress mediated sperm dysfunction and DNA damage.