Serum microRNA expression in pregnancies with preeclampsia

Gunel T., Zeybek Y. G., Akcakaya P., Kalelioglu I., Benian A., Ermis H., ...More

GENETICS AND MOLECULAR RESEARCH, vol.10, no.4, pp.4034-4040, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.4238/2011.november.8.5
  • Journal Name: GENETICS AND MOLECULAR RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.4034-4040
  • Keywords: MicroRNA, Preeclampsia, Non-invasive prenatal diagnosis, MATERNAL PLASMA, MESSENGER-RNA, BIOMARKERS, IDENTIFICATION, DEATH
  • Istanbul University Affiliated: Yes

Abstract

Preeclampsia continues to be a mortal disease of pregnant women throughout the world. Recently, geneticists, allied with obstetricians, have opened new frontiers. MicroRNAs (miRNAs) are members of a class of small, noncoding RNA molecules. They are critical posttranscriptional regulators of gene expression. We extracted circulating miRNA from maternal plasma and quantified mir152 and mir-210. We found up-regulated miR-210 levels as well as down-regulated mir-152 levels in preeclampsia patients. We propose that detection of increased mir-210 levels in maternal serum could be used to improve prediction methods for noninvasive prenatal diagnosis of preeclampsia.