Serum microRNA expression in pregnancies with preeclampsia


Gunel T., Zeybek Y. G. , Akcakaya P., Kalelioglu I., Benian A. , Ermis H., ...More

GENETICS AND MOLECULAR RESEARCH, vol.10, no.4, pp.4034-4040, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.4238/2011.november.8.5
  • Title of Journal : GENETICS AND MOLECULAR RESEARCH
  • Page Numbers: pp.4034-4040

Abstract

Preeclampsia continues to be a mortal disease of pregnant women throughout the world. Recently, geneticists, allied with obstetricians, have opened new frontiers. MicroRNAs (miRNAs) are members of a class of small, noncoding RNA molecules. They are critical posttranscriptional regulators of gene expression. We extracted circulating miRNA from maternal plasma and quantified mir152 and mir-210. We found up-regulated miR-210 levels as well as down-regulated mir-152 levels in preeclampsia patients. We propose that detection of increased mir-210 levels in maternal serum could be used to improve prediction methods for noninvasive prenatal diagnosis of preeclampsia.