IL-1 beta is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence


Akin D., RAVIZZA T., MAROSO M., Carcak N., Eryigit T., VANZULLI I., ...More

NEUROBIOLOGY OF DISEASE, vol.44, no.3, pp.259-269, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 3
  • Publication Date: 2011
  • Doi Number: 10.1016/j.nbd.2011.05.015
  • Journal Name: NEUROBIOLOGY OF DISEASE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.259-269
  • Keywords: Inflammation, Absence seizures, Interleukins, SWD, EXPERIMENTAL FEBRILE SEIZURES, STATUS EPILEPTICUS, GLUTAMATE UPTAKE, EPILEPTOGENESIS, EXPRESSION, MODEL, ACTIVATION, INTERLEUKIN-1-BETA, HIPPOCAMPUS, CYTOKINES
  • Istanbul University Affiliated: Yes

Abstract

Interleukin (IL)-1 beta plays a crucial role in the mechanisms of limbic seizures in rodent models of temporal lobe epilepsy. We addressed whether activation of the IL-1 beta signaling occurs in rats with genetic absence epilepsy (GAERS) during the development of spike-and-wave discharges (SWDs). Moreover, we studied whether inhibition of IL-1 beta biosynthesis in GAERS could affect SWD activity.