The relationship between endothelial nitric oxide synthase 4a/4b gene polymorphism and premature coronary artery disease


Ekmekci A. , Ozcan K. S. , Gungor B., Abaci N. , Osmonov D., Zencirci A., ...Daha Fazla

ACTA CARDIOLOGICA, cilt.68, ss.464-468, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 68 Konu: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1080/ac.68.5.2994468
  • Dergi Adı: ACTA CARDIOLOGICA
  • Sayfa Sayıları: ss.464-468

Özet

Background Nitric oxide (NO) plays a major role in the regulation of endothelial functions and reduced NO synthesis has been implicated in the development of coronary atherosclerosis. Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism has been shown to be related to plasma nitric oxide concentrations and coronary artery disease in various population studies. The aim of this study is to assess the relationship between eNOS 4a/b polymorphism and premature CAD.