The relationship between endothelial nitric oxide synthase 4a/4b gene polymorphism and premature coronary artery disease

Ekmekci A., Ozcan K. S., Gungor B., Abaci N., Osmonov D., Zencirci A., ...More

ACTA CARDIOLOGICA, vol.68, no.5, pp.464-468, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 68 Issue: 5
  • Publication Date: 2013
  • Doi Number: 10.1080/ac.68.5.2994468
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.464-468
  • Istanbul University Affiliated: Yes


Background Nitric oxide (NO) plays a major role in the regulation of endothelial functions and reduced NO synthesis has been implicated in the development of coronary atherosclerosis. Endothelial nitric oxide synthase (eNOS) intron 4a/b polymorphism has been shown to be related to plasma nitric oxide concentrations and coronary artery disease in various population studies. The aim of this study is to assess the relationship between eNOS 4a/b polymorphism and premature CAD.