The safety of live-attenuated vaccines in patients using IL-1 or IL-6 blockade: an international survey

Jeyaratnam, Jerold; ter Haar, Nienke; Lachmann, Helen; Kasapcopur, Özgür; Ombrello, Amanda; Rigante, Donato; Dedeoglu, Fatma; Baris, Ezgi; Vastert, Sebastiaan; Wulffraat, Nico; Frenkel, Joost

doi:10.1186/s12969-018-0235-z

The safety of live-attenuated vaccines in patients using IL-1 or IL-6 blockade: an international survey

Jeyaratnam J., ter Haar N. M., Lachmann H. J., Kasapcopur O., Ombrello A. K., Rigante D., ...More

PEDIATRIC RHEUMATOLOGY, vol.16, 2018 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 16
Publication Date: 2018
Doi Number: 10.1186/s12969-018-0235-z
Journal Name: PEDIATRIC RHEUMATOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Istanbul University Affiliated: Yes

Abstract

Background: Withholding live-attenuated vaccines in patients using interleukin (IL)-1 or IL-6 blocking agents is recommended by guidelines for both pediatric and adult rheumatic diseases, since there is a risk of infection in an immune suppressed host. However, this has never been studied. This retrospective, multicenter survey aimed to evaluate the safety of live-attenuated vaccines in patients using IL-1 or IL-6 blockade.