Curcumin prevents liver fat accumulation and serum fetuin-A increase in rats fed a high-fat diet

Oner-Iyidogan Y., Kocak H., Seyidhanoglu M., Gurdol F., Gulcubuk A., Yildirim F., ...Daha Fazla

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, cilt.69, sa.4, ss.677-686, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 69 Sayı: 4
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s13105-013-0244-9
  • Dergi Adı: JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.677-686
  • Anahtar Kelimeler: Obesity, Curcumin, Fetuin-A, Fatty liver, High-fat diet, ALPHA(2)-HEREMANS-SCHMID GLYCOPROTEIN/FETUIN-A, RECEPTOR TYROSINE KINASE, INSULIN-RESISTANCE, OXIDATIVE STRESS, LIPID-PEROXIDATION, ENERGY-METABOLISM, BLOOD-GLUCOSE, OBESITY-PRONE, DISEASE, ANTIOXIDANT
  • İstanbul Üniversitesi Adresli: Evet

Özet

Fetuin-A is synthesized in the liver and is secreted into the bloodstream. Clinical studies suggest involvement of fetuin-A in metabolic disorders such as visceral obesity, insulin resistance, diabetes, and fatty liver. Curcumin is extracted from the rhizome Curcuma longa and has been shown to possess potent antioxidant, anticarcinogenic, anti-inflammatory, and hypoglycemic properties. In this study, we investigated the effect of curcumin treatment on serum fetuin-A levels as well as hepatic lipids and prooxidant-antioxidant status in rats fed a high-fat diet (HFD). Male Sprague-Dawley rats were divided into six groups. Group 1 was fed control diet (10 % of total calories from fat). Groups 2 and 3 were given curcumin (100 and 400 mg/kg bw/day, respectively ) by gavage for 8 weeks and were fed control diet. Group 4 was fed with HFD (60 % of total calories from fat). Groups 5 and 6 received HFD together with the two doses of curcumin, respectively. Curcumin treatment appeared to be effective in reducing liver triglycerides and serum fetuin-A levels. These findings suggest that the reduction of fetuin-A may contribute to the beneficial effects of curcumin in the pathogenesis of obesity.