The effect of amygdala kindling on neuronal firing patterns in the lateral thalamus in the GAERS model of absence epilepsy

Carcak N., ZHENG T., ALI I., ABDULLAH A., FRENCH C., POWELL K. L., ...Daha Fazla

EPILEPSIA, cilt.55, sa.5, ss.654-665, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 5
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1111/epi.12592
  • Dergi Adı: EPILEPSIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.654-665
  • Anahtar Kelimeler: Amygdala kindling, Absence epilepsy, Ventrobasal thalamic nucleus, In vivo juxtacellular single unit recordings, Mesial temporal lobe epilepsy, WAVE DISCHARGES, TEMPORAL-LOBE, RAT MODEL, ELECTRICAL-STIMULATION, NEURAL INFORMATION, RETICULAR NUCLEUS, SPONTANEOUS SPIKE, LESION PLACEMENT, SEIZURES, RESISTANCE
  • İstanbul Üniversitesi Adresli: Evet

Özet

ObjectiveThe co-occurrence of absence and mesial temporal lobe epilepsy is rare in both humans and animal models. Consistent with this, rat models of absence epilepsy, including genetic absence epilepsy rats from Strasbourg (GAERS), are resistant to experimental temporal lobe epileptogenesis, in particular by amygdala kindling. Structures within the cortical-thalamocortical system are critically involved in the generation and maintenance of the electrographic spike-and-wave discharges (SWDs) that characterize absence seizures. Using in vivo electrophysiologic recordings, this study investigated the role of thalamocortical circuitry in the generalization of amygdala-kindling induced seizures in the GAERS and the nonepileptic control (NEC) strain of Wistar rats.