Novel 4-thiazolidinone derivatives bearing imidazo2,1-bthiazole moiety: design, synthesis, and antiviral activity evaluation

Başoğlu-ünal F., Cimok S., DİNCEL E. D., Naesens L., Ulusoy-Güzeldemirci N.

Journal of Research in Pharmacy, cilt.27, sa.2, ss.924-935, 2023 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.29228/jrp.372
  • Dergi Adı: Journal of Research in Pharmacy
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.924-935
  • Anahtar Kelimeler: 4-thiazolidinone, antiviral activity, coxscakie b4 virus, influenza, Imidazo2,1-bthiazole
  • İstanbul Üniversitesi Adresli: Evet

Özet

This paper aimed to synthesize novel compounds carrying imidazo2,1-bthiazole nucleus, characterize them with various spectroscopic methods, moreover evaluate their antiviral activity. All novel derivatives were evaluated for their antiviral activity against Coxsackie B4 virus, Respiratory syncytial virus, Influenza A/H1N1 virus, Influenza A/H3N2, and Influenza B virus. Some of the compounds, particularly the derivatives carrying 4- methylphenyl and 4-bromophenyl moiety, exhibited higher and comparable activities against both Coxsackie B4 and Respiratory syncytial viruses, moreover the compounds with N-propyl and N-butyl at thiazolidinone ring showed high antiviral activities against Influenza Influenza A/H3N2 viruses. Consequently, the results obtained from in vitro assay data shed light on improving novel antiviral.