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Journal of Research in Pharmacy, vol.27, no.2, pp.924-935, 2023 (Scopus)
This paper aimed to synthesize novel compounds carrying imidazo2,1-bthiazole nucleus, characterize them with various spectroscopic methods, moreover evaluate their antiviral activity. All novel derivatives were evaluated for their antiviral activity against Coxsackie B4 virus, Respiratory syncytial virus, Influenza A/H1N1 virus, Influenza A/H3N2, and Influenza B virus. Some of the compounds, particularly the derivatives carrying 4- methylphenyl and 4-bromophenyl moiety, exhibited higher and comparable activities against both Coxsackie B4 and Respiratory syncytial viruses, moreover the compounds with N-propyl and N-butyl at thiazolidinone ring showed high antiviral activities against Influenza Influenza A/H3N2 viruses. Consequently, the results obtained from in vitro assay data shed light on improving novel antiviral.