Time-level relationship for nitric oxide and the protective effects of aminoguanidine in experimental spinal cord injury

Soy O., Aslan O., Uzun H., Barut S., Igdem A., Belce A., ...More

ACTA NEUROCHIRURGICA, vol.146, no.12, pp.1329-1336, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 146 Issue: 12
  • Publication Date: 2004
  • Doi Number: 10.1007/s00701-004-0343-z
  • Journal Name: ACTA NEUROCHIRURGICA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1329-1336
  • Istanbul University Affiliated: No

Abstract

Background. The secondary injury process following spinal cord trauma has been shown to involve different mechanisms such as excessive release of excitatory amino-acids, and induction of free radical induced lipid peroxidation. In this experimental study, the time-level relationship of the nitric oxide and the neuroprotective effects of aminoguanidine were investigated in a rat spinal cord trauma model.