Akademik Veri Yönetim Sistemi
20th Annual Congress of International Drug Discovery Science and Technology - Japan 2024 (IDDST-Japan 2024), Osaka, Japonya, 22 - 24 Mayıs 2024, ss.10
Neurodegeneration, slow and progressive dysfunction and loss of neurons and axons in the central nervous system, occurs as an undesirable consequence of neuroinflammation, although reactive oxygen species, i.e. free radicals, and inflammation caused by oxidative stress is a response to protect damaged tissues. This leads to acute and chronic neurodegenerative diseases like Alzheimer's disease and Parkinson's disease, as well as neurotropic viral infections, strokes, paraneoplastic disorders, traumatic brain damage and multiple sclerosis. Since the importance of oxidative stress and inflammation in the evolution of these diseases has been demonstrated, the number of studies looking for therapeutic treatments by discovering agents with strong antioxidant and anti-inflammatory potential is increasing by the day.
Fraxinus species contain secoiridoids, phenylethanoids and phenolic compounds, and have various activities such as anticancer, anti-inflammatory, antioxidant and neuroprotective. In addition to various investigations into their high antioxidant and anti-inflammatory effects, our research group discovered that Fraxinus ornus subsp. ornus has also good antioxidant, anti-inflammatory and neuroprotective activities. Although previous study has concentrated on specific species, the goal is to examine and reveal the potential of all investigated Fraxinus species in the treatment of neurodegenerative diseases, including Parkinson's and Alzheimer's.