The probability of residual tumor detection in the second transurethral resection of PT1 urothelial bladder cancer according to the risk factors

Culpan M., Kazan O., Acar H. C., Iplikci A., Atis G., Yildirim A.

ACTAS UROLOGICAS ESPANOLAS, cilt.46, sa.7, ss.423-430, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 7
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.acuro.2021.07.002
  • Dergi Adı: ACTAS UROLOGICAS ESPANOLAS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Gender Studies Database, MEDLINE, DIALNET
  • Sayfa Sayıları: ss.423-430
  • Anahtar Kelimeler: Bladder cancer, Predictive factors, Re-TUR, Residual tumor, Second resection, PREDICTIVE FACTORS, CLINICAL-OUTCOMES, PROGRESSION, RECURRENCE, IMPACT, CARCINOMA, DISEASE, TA
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Objective: To analyze the predictive factors for residual tumors in the second resection after the initial transurethral resection of bladder tumor (TUR-BT) in patients with pT1 tumors and to develop a simple method to predict the probability of residual tumor detection.Material and methods: Patients with pT1 bladder cancer who underwent a second resection within 2 to 6 weeks after the initial transurethral resection of bladder tumor were included in our retrospective study. The patients' demographics and the tumor characteristics of the initial and second resections were recorded.Results: A total of 144 patients were included in our analysis with a 53-month follow-up. In the univariate logistic regression analysis, tumor grade, concomitant carcinoma in situ, macros-copic appearance of the tumor (solid vs papillary), and presence of a variant histology, were significant risk factors for residual tumor. In the multivariate analysis, tumor grade was the only independent predictor of residual tumor at second transurethral resection (OR: 5.62, 95% CI: 1.228-25.708, p = 0.026). According to our findings, the patients with the highest risk have a 90.9% residual tumor detection probability at the second resection, and the patients with the lowest risk have 25.4%Conclusions: Tumor grade, macroscopic appearance of the tumor (solid vs papillary), and conco-mitant carcinoma in situ, were important predictors of residual tumors at second resection of primary pT1 non-muscle invasive bladder cancer patients. We were able to calculate the pro-bability of residual tumor which helped us determine risk adapted strategies according to these probabilities.(c) 2022 AEU. Published by Elsevier Espana, S.L.U. All rights reserved.