The effect of growth hormone treatment on biochemical indices in hypophosphatemic rickets


Darendeliler F. F. , Bas F. , Karaaslan N., Hekim N., Bundak R., Saka N., ...Daha Fazla

HORMONE RESEARCH, cilt.55, sa.4, ss.191-195, 2001 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Konu: 4
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1159/000049994
  • Dergi Adı: HORMONE RESEARCH
  • Sayfa Sayıları: ss.191-195

Özet

Background. Growth hormone (GH) in combination with conventional therapy in hypophosphatemic rickets (HR) has been shown to promote renal phosphate (P) conservation and to result in a better metabolic control. This study aimed at investigating the acute biochemical effects of GH in 7 patients (5 female, 2 male) with HR aged between 2.16 and 16 years. Methods: Each patient received the following in a sequential design: oral P plus 1,25-dihydroxyvitamin D-3 [1,25-(OH)(2)D-3] therapy to determine the optimum doses for baseline requirement followed by GH-only therapy and GH +1,25-(OH)(2)D-3 therapy and GH + P + 1,25-(OH)(2)D-3 therapy each for 2 weeks with 1 washout week off treatment in between. GH was given at a dose of 0.03 mg/kg/day s.c. on a daily basis. The dose of oral P used ranged between 500 and 2,000 mg/day, and the dose of 1,25-(OH)(2)D-3 ranged between 0.25 and 0.5 mug/day and was kept constant for each child throughout the study. Results: Laboratory investigations repeated at the end of each treatment, and the first washout period showed that the serum P level was highest (2.9 ng/ml) during the GH + P + 1,25-(OH)(2)D-3 period with higher serum 1,25-(OH)(2)D-3 levels: 50.9 +/- (SD) 23.4 ng/l. Parathyroid hormone and alkaline phosphatase levels did not show a significant difference between the periods. The tubular P reabsorbtion rate showed an insignificant increase during GH therapy periods. Conclusion: Considering the fixed dose of P and calcitriol, it may be concluded that GH added to conventional treatment in HR resulted in a slight improvement in the biochemical parameters without any side effects at the short term. Copyright (C) 2001 S. Karger AG, Basel.