Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials

Van Poelgeest, Eveline; Prokopidis, Konstantinos; Erdogan, Tuğba; Kwak, Min; Piotrowicz, Karolina; Paoletti, Luca; Eidam, Annette; Koçak, Fatma; Ilhan, Birkan; Beccacece, Alessia; Soulis, George; Özkök, Serdar; Bahat, Gülistan; Topinková, Eva; Daams, Joost; Handoko, M.; Goyal, Parag; Gąsowski, Jerzy; Cherubini, Antonio; Veronese, Nicola; Testa, Giuseppe; Thompson, Wade; Van Der Velde, Nathalie

doi:10.1007/s41999-025-01229-5

Effectiveness and safety of chronic diuretic use in older adults: an umbrella review of recently published systematic reviews and meta-analyses of randomized-controlled trials

Van Poelgeest E., Prokopidis K., Erdogan T., Kwak M. J., Piotrowicz K., Paoletti L., ...Daha Fazla

European Geriatric Medicine, cilt.16, sa.4, ss.1353-1387, 2025 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Derleme
Cilt numarası: 16 Sayı: 4
Basım Tarihi: 2025
Doi Numarası: 10.1007/s41999-025-01229-5
Dergi Adı: European Geriatric Medicine
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
Sayfa Sayıları: ss.1353-1387
Anahtar Kelimeler: Adverse outcome, Benefit, Diuretics, Efficacy, Meta-analysis, Umbrella review
İstanbul Üniversitesi Adresli: Evet

Özet

Aim: This umbrella review aimed to summarize the literature on the efficacy and safety of chronic diuretic treatment in adults. Findings: Certain diuretics or diuretic subclasses offer significant benefits for key clinical outcomes, such as reducing cardiovascular mortality and heart failure-related hospitalizations. However, chronic diuretic use carries potential risks, including an increased risk of hyperkalemia, with age-related differences in adverse event risks [older adults (≥ 65 years) facing higher risks, while younger populations do not show similar concerns]. Message: Further research is needed to establish diuretic efficacy and safety in populations commonly seen in clinical practice, especially older adults living with multimorbidity and frailty.