Aggravation of atonic seizures by rufinamide: A case report.

Bektas G., Caliskan M., Aydin A., Yildiz E., Tatli B., Aydinli N., ...More

Brain & development, vol.38, no.7, pp.654-7, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 7
  • Publication Date: 2016
  • Doi Number: 10.1016/j.braindev.2016.02.005
  • Journal Name: Brain & development
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.654-7
  • Istanbul University Affiliated: Yes


Background: Rufinamide is a novel antiepileptic drug used as adjunctive therapy in patients with Lennox-Gastaut syndrome and provides seizure control especially in tonic and atonic seizures. Rufinamide is expected to be effective in intractable epilepsy when atonic and tonic seizures exist. However, rufinamide induced seizure aggravation has been reported in a few patients, which was not associated with a specific type of seizure.