Relationship between ciprofloxacin resistance and extended-spectrum beta-lactamase production in Escherichia coli and Klebsiella pneumoniae strains

Tolun V., Kucukbasmaci O. , Torumkuney-Akbulut D., Catal C., Ang-Kucuker M., Ang O.

CLINICAL MICROBIOLOGY AND INFECTION, vol.10, no.1, pp.72-75, 2004 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 1
  • Publication Date: 2004
  • Doi Number: 10.1111/j.1469-0691.2004.00723.x
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.72-75


Resistance to fluoroquinolones has increased markedly since their introduction. Mechanisms of resistance to any antibiotic class might play a role in resistance to an unrelated antibiotic class. This study evaluated the relationship between extended-spectrum beta-lactamase (ESBL) production and ciprofloxacin resistance in Escherichia coli and Klebsiella pneumoniae strains isolated as causative agents of urinary tract infection. ESBL-producing strains were significantly more frequent among ciprofloxacin-resistant E. coli strains than among ciprofloxacin-susceptible E. coli strains (p = 0.015), but the difference was not significant among K. pneumoniae strains (p = 0.276).