Akademik Veri Yönetim Sistemi
MASCC/ISOO Annual Meeting on Supportive Care in Cancer, District Of Columbia, Amerika Birleşik Devletleri, 22 - 24 Haziran 2017, ss.1
Effects of denosumab and
bisphosphonates in prostate cancer rat models with chronic gingival inflammation
Osteonecrosis of the jaws
(ONJ) is a significant complication of antiresorptive medications, such as
bisphosphonates and denosumab. Invasive
dental procedures (e.g. tooth extraction), use of prosthesis or periodontal
disease, may increase the risk of osteonecrosis of the jaw.
The aim of the project is to investigate effect of denosumab
and bisphosphonate on development of osteonecrosis in alveolar bone when chronic
gingival inflammation is present.
40 male Cophenagen rats divided into four groups; 1.
Group (B: bisphosphonates), 2. group (D: denosumab), 3. group (C(+): control
and injected with salin ) and 4. group (C(-): without prostate cancer control).
Ligatures were placed and immobilized around right maxillary 1st
molars. One week after prostate cancer induced by ortotropic process,
injections of group Z, D and K(+) were performed intraperitoneally once a week
and the injections were continued for 3 weeks. After 4 weeks the rats
were sacrificed.
Osteopontin levels of group B was
statistically higher from all groups. Parathormone levels of group B was higher
than all groups but only statistically higher from group C(+) (p=0.010).
Osteocalcin levels of group C(-) were found distinctly lower than all groups. As a result
of histopathologic examination only a rat from group B showed, alveolar bone
necrosis (16.66%).
Our study showed that the bisphosphonates may cause
osteonecrosis in the presence of chronic inflammation without any invasive
procedure like dental extraction. However, there was no significant
osteonecrosis formation was detected in the denosumab-treated group. There is a
need for further clinical studies with denosumab.