α-Lipoic Acid Ameliorates The Changes in Prooxidant-Antioxidant Balance in Liver and Brain Tissues of Propylthiouracil-Induced Hypothyroid Rats

Baki A. M., Aydın A. F., Vural P., Olgaç V., Doğru A., Uysal M.

CELL JOURNAL, ss.117-124, 2020 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2020
  • Doi Numarası: 10.22074/cellj.2020.7049
  • Dergi Adı: CELL JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, EMBASE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.117-124
  • Anahtar Kelimeler: Brain, Hypothyroidism, Lipoic Acid, Liver, Prooxidant-Antioxidant Balance, OXIDATIVE STRESS PARAMETERS, LIPID-PEROXIDATION, DEFENSE SYSTEM, DYSFUNCTION, SUPPLEMENTATION, QUERCETIN
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: There are controversial data about the prooxidant-antioxidant balance in hypothyroidism. We aimed to investigate the effect of alpha-lipoic acid (ALA) on oxidative stress parameters in the liver and brain of propylthiouracil (PTU)-induced hypothyroid rats. Materials and Methods: In this experimental study, PTU (500 mg/L) was given to rats in drinking water for 10 weeks. ALA (0.2% in diet) alone and together with thyroxine (T4, 20 mu g/kg body weight, s.c) were given to hypothyroid rats in the last 5 weeks of the experimental period. The levels of reactive oxygen species, malondialdehyde, protein carbonyl, ferric reducing antioxidant power (FRAP) and glutathione (GSH) levels, superoxide dismutase, and GSH peroxidase activities were determined in the liver and brain of rats. Histopathological examinations were also performed. Results: Prooxidant parameters were increased in the brain but not liver in hypothyroid rats. ALA treatment alone lowered enhanced brain oxidative stress in hypothyroid rats. Also, ALA was found to ameliorate the changes as a result of oxidative stress arising from T4 replacement therapy. Conclusion: Our results indicate that ALA alone and together with T4 may be useful in reducing oxidative stress in thyroid dysfunctions.