Frontal brain activation during a Working Memory task: a time-domain fNIRS study

Molteni E., Baselli G., Bianchi A. M., Caffini M., Contini D., Spinelli L., ...Daha Fazla

Conference on Photonic Therapeutics and Diagnostics V, San-Jose, Kostarika, 24 - 26 Ocak 2009, cilt.7161 identifier

  • Yayın Türü: Bildiri / Tam Metin Bildiri
  • Cilt numarası: 7161
  • Doi Numarası: 10.1117/12.808972
  • Basıldığı Şehir: San-Jose
  • Basıldığı Ülke: Kostarika
  • Anahtar Kelimeler: near infrared spectroscopy, optical imaging, time-resolved imaging, working memory, sustained attention, NEAR-INFRARED SPECTROSCOPY, PREFRONTAL CORTEX, ATTENTION, SYSTEM, BOLD, FMRI
  • İstanbul Üniversitesi Adresli: Hayır

Özet

We evaluated frontal brain activation during a working memory task with graded levels of difficulty in a group of 19 healthy subjects, by means of time-resolved fNIRS technique. Brain activation was computed, and was then separated into a "block-related" and a "tonic" components. Load-related increases of blood oxygenation were studied for the four different levels of task difficulty. Generalized Linear Models were applied to the data in order to explore the metabolic processes occurring during the mental effort and, possibly, their involvement in short term memorization. Results attest the presence of a persistent attentional-related metabolic activity, superimposed to a task-related mnemonic contribution. Moreover, a systemic component probably deriving from the extra-cerebral capillary bed was detected.